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AI Internship

Cyclica is seeking an AI Internship to support the continuing development of MatchMaker, a technology based on deep learning that reliably predicts binding between small molecules and human proteins (link). The intern will work within Cyclica’s team of software developers and data scientists to refine the core predictive model used for proteome screening and drug design projects. Please click the icon above for more details.

AI Internship

About Cyclica

Cyclica is a Toronto-based, venture-backed biotechnology company that has recently been named by Deep Knowledge Analytics as one of the top 20 AI in Pharma companies globally. Cyclica provides its web-based drug discovery platform to world-class pharmaceutical, biotechnology, and academic partners to enable the development of safer and more effective medicines.  For more information, see cyclicarx.com.

Role and Responsibilities

The intern will work within Cyclica’s team of software developers and data scientists to refine the core predictive model used for proteome screening and drug design projects. They will become familiar with the MatchMaker codebase and the procedures of data gathering, filtering, and model training. They will keep detailed notes and document their work, using the company’s source code control system (git/gitlab). If applicable, they will aid in the preparation of a manuscript for submission to a peer-reviewed journal.  The intern will have the opportunity to work with Cyclica’s in-house expert data scientists and gain experience working on real-world problems that will make a direct impact and immediate impact on global pharmaceutical R&D.

Project focus

Cyclica has recently developed MatchMaker, a technology based on deep learning that reliably predicts binding between small molecules and human proteins (link). MatchMaker is trained using a combination of structural data and drug-protein interaction data from public databases and has proven to be much more accurate than conventional molecular docking approaches, rivaling high-throughput experimental techniques. The successful applicant will explore new methods to leverage mixed confidence training data to improve model generalizability.

Qualifications and Education Requirements

  • Degree in computer science, mathematics, or a natural science

  • Actively pursuing or recently completed an MSc. degree

  • Proficiency in computer programming, Python mandatory

  • Experience with machine learning and data analysis

  • Familiarity with life sciences (at the molecular level) is desirable, but not mandatory.

Skills Needed

The applicant should be exceptional at programming in Python, and have experience with a machine learning framework such as Tensorflow, Torch, or MXNet.

Location

207 Queens Quay West Toronto, ON M5J 1A7.

Internship Duration

17 contiguous weeks per 4-month internship.  40 hours per week. Flexible start date.

Application Requirements

  • Cover letter

  • Curriculum vitæ

Please submit all application material by March 15th, 2019 to: careers@cyclicarx.com with subject line: `Cyclica - AI Internship’.  Questions may also be directed to careers@cyclicarx.com in advance of the due date.  Note: Successful applicants may be required to provide additional documentation in the form of reference letters and/or transcripts.